It also has potent antioxidant and anti-inflammatory effects.The first thing we need to do is determine the amount of chromium (II) sulfate present in the solution in moles. Preliminary studies suggest that berberine may have benefits against depression, cancer, infections, fatty liver, and heart failure. More research on many of these benefits is necessary before firm recommendations can be made, but the current evidence is promising. Heart failure: One older study showed that it improved symptoms and reduced the risk of death in people with heart failure ( 32).Fatty liver: It may reduce fat buildup in the liver, which could theoretically help protect against NAFLD ( 31).Infections: Test-tube studies suggest that it can reduce the growth of harmful microorganisms, including certain types of bacteria, viruses, and fungi ( 28, 29, 30).Oxidative stress and inflammation: It has been shown to have potent antioxidant and anti-inflammatory effects in some test-tube and animal studies ( 25, 26, 27).Cancer: Test-tube and animal studies suggest that it can reduce the growth and spread of various types of cancer ( 24).Depression: Animal studies suggest that it may help reduce symptoms of depression ( 22, 23).While more research is needed, it may lower the risk of heart disease in the long term.īerberine may have numerous other health benefits: Studies suggest that berberine reduces cholesterol and triglyceride levels while raising HDL (good) cholesterol levels. Given the beneficial effects on all these risk factors, it seems likely that berberine could reduce the risk of heart disease, though more research is needed. This leads to more LDL cholesterol being removed from your bloodstream ( 21).ĭiabetes, high blood sugar levels, and obesity are also major risk factors for heart disease, and this supplement seems to help improve all of these conditions ( 7). It has also been shown to lower apolipoprotein B by 13–15% in some older studies, which is an important risk factor for heart disease ( 19, 20).Īccording to some research, berberine works by inhibiting an enzyme called PCSK9. Many factors that can be measured in your blood are associated with an increased risk of heart disease.Īs it turns out, berberine has been shown to improve many of these factors.Īccording to a review of 16 studies, it could help ( 18): Heart disease is currently the leading cause of death around the globe ( 17). It lowers cholesterol and may reduce your risk of heart disease It may be as effective as some diabetes medications. Summaryīerberine has been shown to help lower blood sugar and HbA1c. It works very well in combination with lifestyle changes and has additive effects when used with other blood sugar-lowering drugs ( 13). It also lowered hemoglobin A1c (HbA1c), a marker of long-term blood sugar regulation, by 12% and improved levels of blood lipids such as cholesterol and triglycerides ( 11).Īccording to an older review of 14 studies, berberine may be as effective as certain oral diabetes drugs, including metformin, glipizide, and rosiglitazone ( 12). In a 2008 study of 116 people with diabetes, taking 1 gram of berberine per day lowered fasting blood sugar by 20% ( 11). increase the number of beneficial bacteria in your gut.slow the breakdown of carbohydrates in your gut.decrease sugar production in your liver.increase glycolysis, helping your body break down sugars inside cells.decrease insulin resistance, making the blood sugar-lowering hormone insulin more effective.It seems to work via multiple mechanisms and may help ( 9, 10): Many studies show that berberine can significantly lower blood sugar levels in people with type 2 diabetes ( 8).
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